Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy
Overview
- Phase
- Phase 4
- Intervention
- Lidocaine
- Conditions
- Postoperative Pain Management
- Sponsor
- Beijing Tongren Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- postoperative pain score
- Last Updated
- 9 years ago
Overview
Brief Summary
This study was to evaluate the effect of intraoperative intravenous lidocaine on postoperative pain management after laparoscopic cholecystectomy. Half of patients will receive intravenous lidocaine during procedure, the rest half of patients will receive regular anesthesia care and placebo treatment.
Detailed Description
Postoperative pain and ileus are primary reasons for delayed patient recovery and longer hospital stays after abdominal surgery. Opioids have been widely used to treat pain in this patient population. However, opioid administration can exacerbate postoperative ileus and further delay patient recovery. Multimodal approaches and adjunctive therapies are therefore recommended for pain control after abdominal surgery to reduce opioid consumption and opioid-related adverse effects. Studies have reported that systemically administered lidocaine has analgesic, anti-inflammatory, and anti-hyperalgesic effects. Several clinical trials have been published that evaluated systemically administered lidocaine for postoperative pain management and recovery after surgery. However, the evidence for beneficial effects of systemic lidocaine for postoperative recovery remains controversial. Therefore, the investigators performed this study to evaluate the efficacy of systemic administration of lidocaine for postoperative analgesia and gastrointestinal recovery after laparoscopic cholecystectomy. The investigators primary hypothesis is that systemic lidocaine administration reduces pain intensity following surgery.
Investigators
YANXIA SUN
Vice-Chief Anesthesiologist
Beijing Tongren Hospital
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologist (ASA) status I-II adult patients undergoing elective laparoscopic cholecystectomy.
Exclusion Criteria
- •Open surgery;
- •Patients allergic to lidocaine or other local anesthetics;
- •Drug abuser.
Arms & Interventions
intravenous lidocaine
intravenous lidocaine 1.5mg/kg during induction then infused at 2mg/kg/h until the end of procedure.
Intervention: Lidocaine
saline placebo
same amount volume saline infusion
Intervention: Saline Placebo
Outcomes
Primary Outcomes
postoperative pain score
Time Frame: 72 hours after surgery
visual analogue score (1-10)
total postoperative opioid consumption
Time Frame: 48 hours after surgery
postoperative fentanyl consumption
Secondary Outcomes
- incidence of postoperative complication(48 hours after surgery)