CT Coronary Angiography and Computational Fluid Dynamics

Not Applicable

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT01189331
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Angiographically obtained fractional flow reserve(FFR) could provide functional and clinical information about stenotic lesion, but the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. CT coronary angiography is non-invasive tool to evaluate lesion severity and lately developing computational fluid dynamics could provide functional information. The investigators build a patient specific model of computational fluid dynamics by CT coronary angiography and evaluate the functional significance by measuring fractional flow reserve via CT coronary angiography and computational fluid dynamics, and investigate its long-term prognostic implications.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10-13
• Study First Submitted: 2010-08-15
• Study First Submitted QC: 2010-08-25
• Study First Posted: 2010-08-26
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-12
• Last Update Posted: 2021-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 103

Inclusion Criteria

• Significant stenosis at CT angiography
• Normal ejection fraction on echocardiography
• Informed consented patient

Exclusion Criteria

• total occlusion and collateral flow to target vessel
• AV conduction abnormality
• Left ventricular hypertrophy
• significant valvular heart or primary myocardial disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
target vessel failure	10 year	composite of cardiovascular death, target vessel myocardial infarction, target vessel revascularization
fractional flow reserve	1day	fractional flow reserve of stenotic coronary artery

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of