Non-invasive Functional Assessment of Coronary Stenoses Using CT Coronary Angiography and Computational Fluid Dynamics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Seoul National University Hospital
- Enrollment
- 103
- Locations
- 1
- Primary Endpoint
- target vessel failure
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Angiographically obtained fractional flow reserve(FFR) could provide functional and clinical information about stenotic lesion, but the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. CT coronary angiography is non-invasive tool to evaluate lesion severity and lately developing computational fluid dynamics could provide functional information. The investigators build a patient specific model of computational fluid dynamics by CT coronary angiography and evaluate the functional significance by measuring fractional flow reserve via CT coronary angiography and computational fluid dynamics, and investigate its long-term prognostic implications.
Investigators
Bon-Kwon Koo
Associate professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Significant stenosis at CT angiography
- •Normal ejection fraction on echocardiography
- •Informed consented patient
Exclusion Criteria
- •total occlusion and collateral flow to target vessel
- •AV conduction abnormality
- •Left ventricular hypertrophy
- •significant valvular heart or primary myocardial disease
Outcomes
Primary Outcomes
target vessel failure
Time Frame: 10 year
composite of cardiovascular death, target vessel myocardial infarction, target vessel revascularization
fractional flow reserve
Time Frame: 1day
fractional flow reserve of stenotic coronary artery