Shorter treatment of catheter related urinary tract infections - SHORTCUT

Academic Medical Center0 sites300 target enrollmentMarch 7, 2018

Overview

No summary available.

Registry

who.int

Start Date

March 7, 2018

End Date

TBD

Last Updated

5 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

Academic Medical Center

•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•1\. Indwelling (transurethral or supra\-pubic) urinary catheter with the intention for long\-term continuous catheterization, at least for the next 28 days
•2\. Signs/symptoms of a systemic UTI, following the modified Loeb criteria \[23,24]:
•a. patient feels sick
•b. at least one of the following signs: Fever \> 37\.9 ºC; Rigors; New onset delirium; New/worsened costovertebral angle tenderness or other local signs of UTI; In patients with spinal cord injury: increase of spasticity \[27]
•3\. Positive dipstick leucocyte esterase test, or sediment \> 10 leucocytes/mm3
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range 150

•1\. Evidence of acute prostatitis or epididymitis
•2\. Negative urine culture after 3 days, sampled before start of antibiotics. A positive urine culture in patients with an indwelling catheter is defined as any growth of uropathogens \[25].
•3\. Insufficient understanding of Dutch or English language, or otherwise unable (cognitively impaired or incapacitated) to understand or cooperate in study, or to give informed consent.
•4\. Patients younger than 18 years of age.
•5\. Current pregnancy
•6\. Patients with kidney transplant.
•7\. Patients with suspected concomitant infection requiring antibiotic treatment
•8\. Patients with growth of S. aureus or Pseudomonas spp in blood culture