Shorter treatment of catheter-related urinary tract infections - SHORTCUT

Academisch Medisch Centrum0 个研究点目标入组 300 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

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•At presentation with current episode of catheter related urinary tract infection:
•1. Indwelling (transurethral or supra-pubic) urinary catheter with the intention for long-term continuous catheterization, at least for the next 28 days
•2. Signs/symptoms of a systemic UTI, following the modified Loeb criteria [23,24]: a. patient feels sick. b. at least one of the following signs: Fever > 37.9 ºC; Rigors; New onset delirium; new/worsened costovertebral angle tenderness or other local signs of UTI; In patients with spinal cord injury: increase of spasticity.
•3. Positive dipstick leucocyte esterase test, or sediment > 10 leucocytes/mm3. If a dipstick or sediment was not performed, a positive urine is needed.

•1. Evidence of acute prostatitis or epididymitis
•2. Insufficient understanding of Dutch or English language, or otherwise unable (cognitively impaired or incapacitated) to understand or cooperate in study, or to give informed consent.
•3. Patients younger than 18 years of age.
•4. Current pregnancy
•5. Patients with kidney transplant.
•6. Patients with suspected concomitant infection requiring antibiotic treatment
•7. Patients with growth of S. aureus or pseudomonas spp in blood culture.
•8. Patients that cannot be treated with (combinations of) the following antibiotics: amoxicillin, amoxicillin/clavulanic acid, cefuroxime, cefotaxime, ceftriaxone, ceftazidime, meropenem, gentamicin, tobramycin, ciprofloxacin, cotrimoxazole, vancomycin.

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