Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Sufentanil
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Enrollment
- 46
- Locations
- 2
- Primary Endpoint
- Tolerance to Simulated Hemorrhage
Study Overview
Brief Summary
This study will examine how sufentanil (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in the research laboratory, participants will complete a test with their lower body in a custom-designed vacuum chamber for a brief period of time.
Detailed Description
Pain management on the battlefield is critical for the wellbeing of the soldier. Given that a hemorrhagic injury on the battlefield is virtually always associated with pain, it is paramount that the selected pain medication does not disrupt appropriate physiological mechanisms that are beneficial towards the maintenance of blood pressure and vital organ blood flow during that hemorrhagic insult. Current guidelines for the selection of pain medications of a hemorrhaging soldier are based upon limited scientific evidence, with the vast majority of supporting studies being conducted on anesthetized animals. Thus, the interaction between hemorrhagic shock and pain medications commonly employed on the battlefield is yet to be determined in the conscious humans.
This study will test the hypothesis that sufentanil will impair the capacity for a conscious human to tolerate a hemorrhagic insult.
The obtained data will provide the necessary scientific evidence in humans to support the Committee on Tactical Combat Casualty Care (CoTCCC) guidelines on the analgesic of choice for moderate to severe injuries where the casualty is in hemorrhagic shock. Notably, such data will identify the analgesic that least compromises a human's ability to tolerate a hemorrhagic insult, ultimately providing critical information to the combat medic on which analgesic should be employed for such an injury.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18-45 years of age
- •Non-obese (body mass index less than 30 kg/m2)
- •Body mass greater than or equal to 65 kg
- •Speak English
Exclusion Criteria
- •Subjects not in the defined age range
- •Subjects who have cardiac, respiratory, neurological and/or metabolic illnesses
- •Any known history of renal or hepatic insufficiency/disease
- •Pregnancy or breast feeding
- •Body mass less than 65 kg
- •Current smokers, as well as individuals who regularly smoked within the past 3 years
- •Subjects who cannot speak or read English
- •Positive urine drug screen
- •Currently taking pain modifying medication(s)
Arms & Interventions
Sufentanil
Sufentanil (30 microgram tablet) will be administered via a sublingual pill
Intervention: Sufentanil (Drug)
Placebo
Placebo will be administered via a sublingual pill
Intervention: Placebo (Other)
Outcomes
Primary Outcomes
Tolerance to Simulated Hemorrhage
Time Frame: 6 hours
Tolerance to a simulated hemorrhagic challenge will be assessed, for both the placebo and sufentanil limbs, by causing progressive central hypovolemia via lower-body negative pressure. This progressive lower-body negative pressure (LBNP) challenge will be performed until the onset of syncopal symptoms (defined as: profound bradycardia, a precipitous drop in arterial blood pressure and accompanying narrowing of pulse pressure, a sustained systolic blood pressure less than 80 mmHg, and/or subjective symptoms such as light-headedness, sweating, nausea, or dizziness). The primary variable will be the quantification of lower-body negative pressure that is required to cause these symptoms. This quantification will be objectively measured via a cumulative stress index which is calculated as the sum of the product of the LBNP level and the duration of each level, until test termination (i.e., 40 mmHg x 3 min + 50 mmHg x 3 min, etc).
Secondary Outcomes
- Pain Assessment(6 hours)
Investigators
Craig Crandall
Professor of Internal Medicine
University of Texas Southwestern Medical Center