europathic pain and Proprioceptive Acuity in Knee osteoarthritis

Completed

Conditions: degenerative arthritis
Osteoarthritis
10023213

Registration Number: NL-OMON44621

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

• Clinical symptoms of primary symptomatic knee osteoarthritis (judged by an experienced clinician);
• Kellgren and Lawrence grade (Anterior-posterior view) >= 1 (X-ray made < 12 months prior to enrolment).

Exclusion Criteria

• Surgical procedures on lower index extremity <= 6 months ago;
• Arthroscopy <= 3 months ago;
• Medical history of significant peripheral nerve injury in the index extremity (e.g. diabetic neuropathy);
• Acute knee or tendon injuries (or other trauma explaining the knee pain);
• Medical history of severe cognitive and/or neurological/neuromuscular disorders (e.g. dementia, MS);
• ASA-score: >= IV;
• Unable to sit or lie on one side to do the TTDPM measurements correctly;
• Reading difficulties, blind, or difficulties with the Dutch language.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Joint motion sense expressed by the threshold to detect passive motion (TTDPM)<br /><br>in degrees and neuropathic pain, defined by the score on the knee-specific<br /><br>Dutch modified-painDETECT questionnaire. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Joint positioning sense (determined with Mr Cube) expressed by the deviation<br /><br>in millimetres from a marker and neuropathic pain, defined by the score on the<br /><br>knee-specific Dutch modified-painDETECT questionnaire.<br /><br><br /><br>2) Pain catastrophizing, determined by continuous score on the pain<br /><br>catastrophizing scale (PCS) and motion and positioning sense. Motion sense is<br /><br>defined by the threshold to detect passive motion (TTDPM) in degrees and the<br /><br>joint position sense is expressed as the deviation in millimetres from a marker<br /><br>(determined with Mr Cube). </p><br>