Antibodies and Immunity After Vaccination of Recovered Patients With COVID-19 and Long COVID-19 Symptoms

• Conditions: Long COVID-19

• Registration Number: NCT05484700
• Lead Sponsor: Mahidol University

Brief Summary

We investigated the association between immune system responsibilities in Long COVID patients and Full recovery patients.

Detailed Description

This retrospective cohort study compared immunogenicity post COVID-19 between individuals (aged 18-65 years and had confirmed SARS-CoV-2 infection from January to May 2022 ) with residual Long COVID-19 symptoms (LC) and ones with full recovery (Full) related to pathophysiology, immunology and clinical consequence.

Study Timeline

• Study Start: 2021-12-30
• Primary Completion: 2022-07-25
• Status Verified: 2022-08
• Study First Submitted: 2022-08-01
• Study First Submitted QC: 2022-08-01
• Study First Posted: 2022-08-02
• Last Update Submitted: 2022-08-03
• Last Update Posted: 2022-08-05
• Study Completion: 2022-12-29

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 305

Inclusion Criteria

• Long COVID group; at longer than 1-month post COVID-19 based the presence of one of the three following symptoms: fatigue/myalgia, breathlessness, and anorexia
• Full recovery group; patients with asymptomatic symptoms
• post COVID-19 they had not received any additional COVID vaccine

Exclusion Criteria

• people who received additional vaccination after leaving quarantine before the day of the immunization test
• pregnant patients,
• people who had a history of allergic reactions after COVID-19 vaccination or any drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anti-SARS-CoV-2 NP	Baseline	surrogate Virus Neutralization Test (sVNT) (PRNT50 titer)
Microneutralization assays	Baseline	Microneutralization assays using the authentic SARS-CoV-2 viruses
Anti-SARS-CoV-2 RBD IgG	Baseline	anti-SARS-CoV-2 receptor-binding domain immunoglobulin G(BAU/mL)

Secondary Outcome Measures

Name	Time	Method
Number of vaccine injection	Baseline	Number of vaccine injection
Prevalence of Long COVID-19 symptoms	Baseline	Number of participants with major Long COVID-19 symptoms including fatigue/myalgia, breathlessness, and anorexia by using the questionnaire

Trial Locations

Locations (1)

Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok Noi, Bangkok, Thailand