Cardiovascular remodeling in small-for-gestational-age fetuses
Recruiting
- Conditions
- Fetal programming, cardiovascular remodeling, late-onset intrauterine growth restrictionPregnancy and ChildbirthLate-onset intrauterine growth restriction
- Registration Number
- ISRCTN36008820
- Lead Sponsor
- Else Kröner-Fresenius Foundation (Else Kröner-Fresenius-Stiftung)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
1. Pregnant women aged 18 and older
2. Fetuses with a gestational age = 32 weeks
3. Suspected of growth restriction defined as an estimated fetal weight or fetal abdominal circumference measured below the 10th population or customized percentile or a change of abdominal circumference <5mm in 2 weeks measured by ultrasound
Exclusion Criteria
1. Born <37 weeks gestational age
2. Known chromosomal and/or structural anomaly
3. Multiple gestation
4. Mothers with cardiac heart disease
5. Mothers’ severe systemic disease
6. Antihypertensive medication
7. Antenatal intra-uterine infection
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prediction of mean blood pressure (BP) (in mmHg) at one year of age is measured using the average acceleration capacity (bpm), tricuspid annular plane systolic excursion (mm), right sphericity index, Strain-rate, aortic distensibility, isovolumetric relaxation time (ms)) during pregnancy.
- Secondary Outcome Measures
Name Time Method