JPRN-UMIN000019215招募中未知
The research for immunological alteration in the pathogenesis of chronic inflammatory skin diseases including psoriasis, atopic dermatitis, SLE. - The immunological alteration in the chronic inflammatory skin diseases
Department of Dermatology, Kochi Medical School, Kochi University0 个研究点目标入组 100 人开始时间: 2016年1月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 100
研究概览
简要总结
TNF inhibitors directly target Th17 cells via attenuation of autonomous TNF/TNFR2 signalling in psoriasis. In vitro Th17-polarized cells from PBMC produced TNF-a in FACS analysis. In addition, TH17-polarized cells exhibited inceased expression of TNFR2. FACS and ELISA confirmed the reduction of IL-17A proteins levels by THF inhibitor. The treatment with anti-TNFR2 significantly down-regulated the production of IL-17A from Th17 cells from psoriasis patients as well as treatment with TNF inhibitor.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •Patients with other inflammatory skin diseases
研究者
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