Comparison of Morphine and Fentanyl/Midazolam in Intensive Care Unit

Not Applicable

Completed

• Conditions: Respiratory Failure
• Interventions: Drug: Morphine infusion; Drug: Fentanyl and Midazolam infusion

• Registration Number: NCT01602640
• Lead Sponsor: Clínica de Los Andes IPS

Brief Summary

Hypothesis: Morphine infusion decreases time to mechanical ventilation weaning and extubation, as compared to the combination of fentanyl and midazolam in critically-ill patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01
• Primary Completion: 2012-02
• Study Completion: 2012-03
• Study First Submitted: 2012-04-18
• Status Verified: 2012-05
• Study First Submitted QC: 2012-05-17
• Last Update Submitted: 2012-05-17
• Study First Posted: 2012-05-21
• Last Update Posted: 2012-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Adults admitted to ICU requiring mechanical ventilation Informed consent

Exclusion Criteria

• Less than 18 years old
• Consent denial

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Morphine	Morphine infusion	-
Fentanyl and Midazolam	Fentanyl and Midazolam infusion	Control

Primary Outcome Measures

Name	Time	Method
Time from sedation discontinuation to first T-Tube time from sedation	12-120 hours

Secondary Outcome Measures

Name	Time	Method
Time from sedation discontinuation to extubation time from sedation	12-180 hours

Trial Locations

Locations (1)

Clinica de los Andes IPS; 🇨🇴 Tunja, Boyaca, Colombia