Chronic Inflammation and Exercise Responsiveness

Mayo Clinic1 site in 1 country146 target enrollmentMarch 2016

ConditionsMetabolic Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Metabolic Syndrome
Sponsor: Mayo Clinic
Enrollment: 146
Locations: 1
Primary Endpoint: Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.

Registry

clinicaltrials.gov

Start Date

March 2016

End Date

December 31, 2021

Last Updated

4 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Mayo Clinic

Responsible Party

Principal Investigator

Ian R. Lanza

Associate Professor of Medicine

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

•Age 30-55 years
•BMI 19-45 kg/m2

Exclusion Criteria

•Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
•Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
•Renal insufficiency/failure (serum creatinine \> 1.5mg/dl)
•Oral warfarin group medications or history of blood clotting disorders.
•Pregnancy or breastfeeding
•Alcohol consumption greater than 2 glasses/day or other substance abuse
•Untreated or uncontrolled thyroid disorders
•Debilitating chronic disease (at the discretion of the investigators)