The Ability of the Change in Positional Perfusion Index in Predicting Post-spinal Anesthesia Hypotension in Caesarian Section

Completed

• Conditions: Obstetric Anesthesia Problems

• Registration Number: NCT05269407
• Lead Sponsor: Cairo University

Brief Summary

Our study aims to investigate the value of postural perfusion index changes as a non-invasive method to predict hypotension following spinal anesthesia for elective cesarean delivery.

Detailed Description

The perfusion index is the ratio of pulsatile blood flow to non-pulsatile in peripheral tissues and can be measured non-invasively using a pulse oximeter .Perfusion index measurement is considered a non-invasive rapid indicator of microcirculation variation and can help to detect circulation disturbance.It also can assess peripheral perfusion dynamics resulting from changes in peripheral vascular tone. Perfusion index changes according to posture with its highest value in Trendelenburg position and lowest value during 45-degree sitting position. However, to the best of our knowledge, no studies have studied the effect of posture on perfusion index in a full-term pregnancy, and its ability to predict hypotension following spinal anesthesia for elective cesarean delivery.

A previous study had found a correlation between baseline perfusion index and the incidence of post-spinal hypotension in the cesarean section, however, they haven't studied the effect of postural change on PI and its predictability of post-spinal induced hypotension(,Our study aims to investigate the value of postural perfusion index changes as a non-invasive method to predict hypotension following spinal anesthesia for elective cesarean delivery.

Study Timeline

• Study First Submitted: 2022-02-26
• Study First Submitted QC: 2022-02-26
• Study First Posted: 2022-03-08
• Study Start: 2022-03-20
• Primary Completion: 2023-03-18
• Study Completion: 2023-03-19
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-14
• Last Update Posted: 2023-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• ASA physical status 1-2 Age > 18 years uncomplicated singleton pregnancy at full-term Elective scheduled caesarian section under spinal anesthesia

Exclusion Criteria

• pre-existing hypertension gestational hypertension or preeclampsia Diabetes mellitus, or autonomic neuropathy Patients with peripheral vascular diseases known fetal abnormality. Emergency caesarian section. Placenta previa or placenta accrete. absolute contraindications or failure to perform spinal anesthesia.Study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sensitivity of positional index in predicting post-spinal hypotension	30 minutes post spinal anesthesia	The sensitivity of perfusion index postural change in predicting post-spinal anesthesia hypotension in caesarian section. surgeries.

Secondary Outcome Measures

Name	Time	Method
The sensitivity of sitting perfusion index to predict post-spinal anesthesia hypotension in caesarian section.	30 minutes post spinal anesthesia	The sensitivity of sitting perfusion index to predict post-spinal anesthesia hypotension in caesarian section.
The sensitivity of supine perfusion index to predict post-spinal anesthesia hypotension in caesarian section.	30 minutes post spinal anesthesia	The sensitivity of sitting perfusion index to predict post-spinal anesthesia hypotension in caesarian section.
The correlation between perfusion index postural change and the degree of severity of hypotension in caesarian section post spina anesthesia.	30 minutes post spinal anesthesia	The correlation between perfusion index postural change and the degree of severity of hypotension in caesarian section post spina anesthesia.

Trial Locations

Locations (1)

Faculty of Medicine; 🇪🇬 Cairo, Egypt