Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

Recruiting

• Conditions: Pituitary Tumors
• Interventions: Other: no interventions between two groups

• Registration Number: NCT05634655
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-12
• Study Start: 2022-01-01
• Study First Submitted: 2022-11-23
• Study First Submitted QC: 2022-12-01
• Last Update Submitted: 2022-12-01
• Study First Posted: 2022-12-02
• Last Update Posted: 2022-12-02
• Primary Completion: 2022-12-31
• Study Completion: 2025-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• 1. histologically confirmed PAs, 2) Non-function pituitary adenomas

Exclusion Criteria

• 1. Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
invasive PAs	no interventions between two groups	-
non-invasive PAs	no interventions between two groups	-

Primary Outcome Measures

Name	Time	Method
Residual tumor size	1 week after surgery	Tumor size was evaluated by postoperative MRI
tumor recurrence	three years	During the follow-up, the tumor recurrence was observed closely

Trial Locations

Locations (1)

2ndAffiliated Hospital, School of Medicine; 🇨🇳 Hanzhou, Zhejiang, China