Regulation of DNA methylation modification of Mesenchymal Stem Cells by Kidney-marrow Simultaneous Therapy in the treatment of osteoarthritis
Not Applicable
- Conditions
- Osteoarthritis
- Registration Number
- ITMCTR2000003227
- Lead Sponsor
- First affiliated hospital of Zhejiang Chinese Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1. Western medicine diagnosis: in 2018, the Chinese society of bone sciences revised the KOA clinical diagnostic criteria;
2. The average age of KOA patients was between 55 and 75 years old and required knee replacement.
Exclusion Criteria
1. With other diseases affecting bone metabolism;
2. With rheumatoid diseases, such as systemic diseases, spondylitis or rheumatoid arthritis;
3. With a history of severe joints.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Imaging;WOMAC score;VAS score;Dnmt3b expression;
- Secondary Outcome Measures
Name Time Method