Identification of DNA methylation markers for plasma-based detection of advanced colorectal adenomas.
Withdrawn
- Conditions
- 1001798710017934sporadic advanced colorectal adenomasporadic high-risk colorectal polyps
- Registration Number
- NL-OMON41939
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 371
Inclusion Criteria
- >45 years
- scheduled for screening colonoscopy or subsequent polypectomy. Indications for screening colonoscopy are rectal blood loss, anemia, change in bowel habits, positive iFOBT or positive family history of adenomas or CRC (two or more first degree relatives or one or more at age 50 years or less).
Exclusion Criteria
- having hereditary colorectal cancer syndrome (e.g. Lynch syndrome or polyposis syndromes) or suspicion thereof
- having inflammatory bowel disease
- previous adenoma
- cancer within the past five years
- colonoscopy that is incomplete or associated with a poor preparation
- lack of histological classification of polyps removed at screening colonoscopy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in DNA methylation of a certain adenoma subtype and normal mucosa of<br /><br>controls.<br /><br>Difference in cfDNA methylation of screening colonoscopy patients with advanced<br /><br>adenoma and those found to be free of colorectal polyps/cancer and<br /><br>inflammation. .</p><br>
- Secondary Outcome Measures
Name Time Method <p>Difference in DNA methylation of a certain adenoma subtype and leucocytes of<br /><br>controls, (pre)malignant tissue from cancer other than CRC or inflammatory<br /><br>conditions, or non-advanced polyps.<br /><br>Difference in cfDNA methylation of screening colonoscopy patients with advanced<br /><br>adenoma and those with non-advanced polyps.</p><br>