DNA methylation profiling in blood of patients with cutaneous squamous cell carcinoma (cSCC) after organ transplantatio

Completed

• Conditions: orgaantransplantatie; post-transplant cutaneous squamous cell carcinoma; post-transplant skin cancer; 10040900

• Registration Number: NL-OMON42690
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients with (cases) compared to patients without (controls) cutaneous squamous cel carcinoma after their first organ transplantation

Exclusion Criteria

Previous transplantation (either solid or non-solid organ transplantation)
History and presence of other malignancies (including skin malignancies before transplantation)
Under 18 years of age

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is the difference in DNA methylation in CD3+ T<br /><br>cells between organ transplant recipients who developed cSCC and organ<br /><br>recipients who did not develop a malignancy.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>