Follicular fluid and plasma derived exosomal DNA methylation in polycystic ovary syndrome
Active, not recruiting
- Conditions
- Polycystic ovary syndrome (PCOS) in infertile women who seeking infertility treatment with in vitro fertilization (IVF)PCOS, DNA methylation, exosome, follicular fluid, epigenetics, CYP19A1
- Registration Number
- TCTR20230831001
- Lead Sponsor
- Program Management Unit for Human Resources & Institutional Development,Research and Innovation (PMU-B)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
1. Female age 18-42 year old
2. Diagnosed as PCOS according to International Evidence-Based Guideline for the Assessment and Management of Polycystic ovary syndrome 2018
Exclusion Criteria
1. Diagnosed as any cancer
2. Diagnosed as endometriosis
3. Diagnosed as PCOS mimicking diseases such as Cushing syndrome, Adult onset adrenal hyperplasia, thyroid disease
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method DNA methylation level in follicular fluid exosome at the end of recruitment Methylation specific PCR
- Secondary Outcome Measures
Name Time Method DNA methylation level in cumulus cell at the end of recruitment Methylation specific PCR