A pilot study of urine DNA methylation alteration in Non-muscle invasive bladder cancer in Thailand, a potential for diagnosis and surveillance.

• Conditions: on-muscle invasive bladder cancer; Non-muscle invasive bladder cancer; NMIBC

• Registration Number: TCTR20210813003
• Lead Sponsor: Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-13
• Study Completion: 2022-08-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Adults older than 18 year-old diagnosed with non-muscle invasive bladder cancer by TURBT with pathologic confirmation

Exclusion Criteria

1. small tissue which cannot be clarified by pathologist
2. benign tumor
3. other tumor apart from urothelial carcinoma
4. muscle invasive bladder cancer
5. prior radiation therapy
6. Previously diagnosed other cancer with prior chemotherapy or radiation therapy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rine DNA methylation genes 1 month after specimen collection DNA methylation CPG hotspot

Secondary Outcome Measures

Name	Time	Method
rine DNA methylation genes in Thailand compared to TCGA database 3 months after population data collection ends DNA methylation CPG hotspot