Differential DNA methylation in the TNFa gene in patients with severe generalised periodontitis
- Conditions
- severe forms of periodontitisType II chronic periodontitis (K05.1)A localizedB generalizedType III aggressive periodontitisA localizedB generalizedK05.1Chronic gingivitis
- Registration Number
- DRKS00003531
- Lead Sponsor
- Martin-Luther-Universität Halle-WittenbergMedizinische FakultätZentrum für Zahn-Mund- und KieferheilkundeUniversitätspoliklinik für Zahnerhaltungskunde und Parodontologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 102
Inclusion Criteria
unrelated persons
Caucasian origin from Central Germany
> 18 years old
periodontal healthy:- no attachment loss (probing depth = 3.5 mm, no gingival recession due to periodontitis,
severe Period: - attachment loss in at least 30% of the teeth with a minimum pocket depth of 4 mm
Exclusion Criteria
Pregnancy
Therapy with antibiotics within the last 3 month
Periodontal therapy within the last 6 month
History of diseases associated with periodontitis
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of DNA methylation pattern in selected cytokine genes in patients with and without periodontitis
- Secondary Outcome Measures
Name Time Method Comparison of mRNA- and protein-expression in selected cytokine genes in patients with and without periodontitis