checking the effect of scaling in patients with gum diseases having Diabetes by measuring Maresin ( marker for tissue injury due to infection ) in saliva

Completed

• Conditions: Chronic periodontitis,

• Registration Number: CTRI/2023/06/053895
• Lead Sponsor: DIVYA M

Brief Summary

This is a pilot clinical trial. The trial included 22 periodontitis patients and 21 periodontitis patients associated with type 2 diabetes mellitus. I got written informed consent from all the participants. I recorded the clinical parameters and performed scaling and root planing for all patients. I collected 5ml salivary samples before treatment and 1 month after treatment for evaluation of salivary Maresin level. The participants were recalled after 1 month for review. 6 patients from group 1 and 10 patients from group 2 were dropped out due to not showing up for the recall visit. I performed ELISA processing to evaluate the salivary Maresin level before and after treatment.  The results show, decreased salivary maresin levels in both groups before the treatment, indicating the chronicity of both the diseases. whereas, after treatment, the salivary maresin levels were increased which depicts tissue return back to homeostasis and accelerates wound healing. This Maresin biomarker can be used as a chairside diagnostic and prognostic test and also it can be used as a novel host-modulating agent. But further larger clinical trials will ensure the results.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-15
• Last Update Posted: 2024-02-27
• Study Completion: 2024-08-02

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

GROUP 1 : Periodontitis without diabetes mellitus GROUP 2 : Periodontitis with type II diabetes mellitus.

Exclusion Criteria

Systemic disease other than type 2 diabetes mellitus Antibiotics / Anti- inflammatory drugs for the past 6 months Smokers Pregnant women Lactating mothers Treatment for periodontal disease within the last 6 months Involvement in another clinical study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maresin salivary levels	Baseline and | 3 months - post intervention

Secondary Outcome Measures

Name	Time	Method
Probing pocket depth	Clinical attachment level

Trial Locations

Locations (1)

K.S.R. Institute of Dental Science & Research; 🇮🇳 Namakkal, TAMIL NADU, India

K.S.R. Institute of Dental Science & Research

🇮🇳Namakkal, TAMIL NADU, India

DIVYA M

Principal investigator

9514728537

divi7812@gmail.com