the Effect of Vitamin D on the Serum Thioredoxin, TBP-2, Thioredoxin Reductase, Gene Expression of TBP-2 in Patients With Type II Diabetes
试验速览
- 阶段
- 4 期
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- serum total cholesterol
研究概览
简要总结
The aim of this study is the comparision between the effects of vitamin D or placebo supplementation for 2 months in serum level of thioredoxin, TBP-2 and thioredoxin reductase activity in patients with type 2 diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •literate, willingness to participation, diabetic patients 30- 60 years old, body mass index in the range 18.5- 35, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention -
排除标准
- •people who have used vitamin D supplements in last 3 months, having chronic renal disease , GI disease, Hepatobilliary diseases, hematological disorders, hypo- or hyperthyroidism, treatment with orlistat or sibutramine for weight loss, pregnancy and lactation, treatment with insulin or Thiazolidinediones, Smokers
结局指标
主要结局
serum total cholesterol
时间窗: change from baseline at 2 months
serum HDL cholesterol
时间窗: change from baseline at 2 months
serum triglycerides level
时间窗: change from baseline at 2 months
fasting plasma glucose
时间窗: change from baseline at 2 months
serum LDL cholesterol
时间窗: change from baseline at 2 months
complete blood count (CBC)
时间窗: change from baseline at 2 months
HbA1c
时间窗: change from baseline at 2 months
serum insulin
时间窗: change from baseline at 2 months
serum calcidiol
时间窗: change from baseline at 2 months
thioredoxin
时间窗: change from baseline at 2 months
thioredoxin binding protein 2 (TBP-2)
时间窗: change from baseline at 2 months
erytrocyte thioredoxin reductase
时间窗: change from baseline at 2 months
次要结局
- GENE EXPRESSION OF TBP-2(change from baseline at 2 months)