PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease

Completed

• Conditions: Alzheimer Disease

• Registration Number: NCT06180252
• Lead Sponsor: IRCCS San Raffaele

Brief Summary

The aim of this study is to understand regional variations in acetylcholine esterase activity in Alzheimer's disease. In this study the aim is to identify by PET the physiological values of the regional activity of acetylcholine esterase using the 11C PM4 tracer and to study by PET and 11C PM4 the brain activity of acetylcholine esterase in a group of patients with Alzheimer's disease, enrolled according to the inclusion and exclusion criteria. The PET data will be correlated with the clinical, neuropsychological and morphological data acquired by MRI and with the clinical-cognitive outcome.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-05-12
• Primary Completion: 2008-01-29
• Study Completion: 2008-01-29
• Status Verified: 2023-12
• Study First Submitted: 2023-12-12
• Study First Submitted QC: 2023-12-12
• Last Update Submitted: 2023-12-12
• Study First Posted: 2023-12-22
• Last Update Posted: 2023-12-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients diagnosed with Alzheimer's disease;
• patients must have undergone an instrumental morphological examination to exclude other neurological pathologies.

Exclusion Criteria

• positive history of major head trauma;
• clinically active somatic diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PET with 11C MP4 as a tracer to identify acetylcholine esterase values in patients with neurodegenerative diseases.	4 years	Development of a new PET method for the in vivo measurement of acetylcholine esterase activity at the cortical level to be used as an indicator of the presence of disease.