Investigation of altered sensory nerve fibre structure and function using quantitative sensory testing and skin biopsy in patients with lumbar radiculopathy and radicular leg pain

Brigitte Tampin0 个研究点目标入组 20 人开始时间: 2020年11月4日最近更新: 2020年11月9日

适应症

试验速览

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•Inclusion criteria for symptomatic participants: symptom duration of > 3 months; clinical diagnosis of L5 or S1 lumbar sensory radiculopathy (defined as conduction block along a spinal nerve or nerve root, manifesting clinically with dermatomal sensory loss) with lower back and radicular leg pain; demonstrable clinically relevant abnormality on imaging studies indicating nerve root compromise at the relevant spinal level. Waitlisted for surgery.
•Inclusion criteria for healthy controls: age 18 to 65 years; participants are required to be age- & sex-matched to symptomatic participants; participant is willing and able to give informed consent for participation in the study.

•Exclusion criteria for symptomatic participants: Diabetes and vascular disease; other neurological or psychiatric disorder; pregnancy, central nervous lesions; previous lumbar surgery; an insufficient level of English to understand and fill out questionnaires and to understand the instructions/requirements for the QST procedures
•Healthy control subjects with a history of current pain or a chronic pain condition or any of the exclusion criteria described for the symptomatic participant group will be excluded, including taking medications that influence pain perception (e.g. analgesics, non-steroidals, antidepressants).

发起方

Brigitte Tampin