Investigation of sensory nerve fibre alterations in people with sciatica

Not Applicable

• Conditions: Neurological - Other neurological disorders; umbar radiculopathy with radicular pain; Lumbar radiculopathy with radicular pain; Surgery - Other surgery

• Registration Number: ACTRN12620001158954
• Lead Sponsor: Brigitte Tampin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-04
• Last Update Posted: 9 November 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Inclusion criteria for symptomatic participants: symptom duration of > 3 months; clinical diagnosis of L5 or S1 lumbar sensory radiculopathy (defined as conduction block along a spinal nerve or nerve root, manifesting clinically with dermatomal sensory loss) with lower back and radicular leg pain; demonstrable clinically relevant abnormality on imaging studies indicating nerve root compromise at the relevant spinal level. Waitlisted for surgery.

Inclusion criteria for healthy controls: age 18 to 65 years; participants are required to be age- & sex-matched to symptomatic participants; participant is willing and able to give informed consent for participation in the study.

Exclusion Criteria

Exclusion criteria for symptomatic participants: Diabetes and vascular disease; other neurological or psychiatric disorder; pregnancy, central nervous lesions; previous lumbar surgery; an insufficient level of English to understand and fill out questionnaires and to understand the instructions/requirements for the QST procedures
Healthy control subjects with a history of current pain or a chronic pain condition or any of the exclusion criteria described for the symptomatic participant group will be excluded, including taking medications that influence pain perception (e.g. analgesics, non-steroidals, antidepressants).

Study & Design

• Study Type: Observational
• Study Design: Not specified