Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients

Completed

• Conditions: Heart Failure, Diastolic; Heart Failure, Systolic

• Registration Number: NCT02946476
• Lead Sponsor: Ospedale Maggiore Di Trieste

Brief Summary

To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Primary Completion: 2013-12
• Study Completion: 2014-12
• Status Verified: 2016-10
• Study First Submitted: 2016-10-25
• Study First Submitted QC: 2016-10-25
• Last Update Submitted: 2016-10-25
• Study First Posted: 2016-10-27
• Last Update Posted: 2016-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2314

Inclusion Criteria

• All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit

Exclusion Criteria

• We excluded all patients who had severe primary left-sided valvular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
overall mortality	2 years

Secondary Outcome Measures

Name	Time	Method
noncardiovascular hospitalization	2 years
First all-cause hospitalization	2 years
Heart Failure hospitalization	2 years