Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients
- Conditions
- Heart Failure, DiastolicHeart Failure, Systolic
- Interventions
- Other: prognostic impact of non cardiac comorbidities
- Registration Number
- NCT02946476
- Lead Sponsor
- Ospedale Maggiore Di Trieste
- Brief Summary
To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2314
- All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit
- We excluded all patients who had severe primary left-sided valvular disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HFrEF prognostic impact of non cardiac comorbidities patients with heart failure and reduced ejection fraction HFpEF prognostic impact of non cardiac comorbidities patients with heart failure and preserved ejection fraction
- Primary Outcome Measures
Name Time Method overall mortality 2 years
- Secondary Outcome Measures
Name Time Method noncardiovascular hospitalization 2 years First all-cause hospitalization 2 years Heart Failure hospitalization 2 years