Effects of Combined Heat Application and Acupressure to the Carotid Artery Region on Cerebral Blood Flow in Healthy Adults: An Investigator-Initiated, Single-Group, Single-Center, Prospective Case Study
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- A SPECT CT brain scan
Overview
Brief Summary
The aim of this study is to investigate the effects of combined heat application and acupressure to the carotid artery region on cerebral blood flow in healthy adults
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 40 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Adults aged 40 to 65 years.
- •Individuals with no history of cerebrovascular, cardiovascular, or neurological diseases.
- •Individuals who have signed the informed consent form and voluntarily agreed to participate in the study
Exclusion Criteria
- •Individuals with a history of cerebrovascular, cardiovascular, or neurological diseases (e.g., stroke, angina, epilepsy).
- •Individuals currently taking medications that may affect cerebral blood flow (such as antihypertensive agents or antidepressants).
- •Individuals with skin diseases or lesions that make it difficult to apply heat or acupressure devices to the carotid artery region, and individuals who are pregnant or breastfeeding.
- •Individuals with a history of seizures.
- •Individuals who have participated in clinical studies two or more times in the same year, or who have participated in another clinical study within the past 6 months.
- •Individuals who, in the judgment of the principal investigator or sub-investigator, have clinically significant findings that make them unsuitable for participation in this study.
Outcomes
Primary Outcomes
A SPECT CT brain scan
Time Frame: In the post-SPECT protocol, the radiopharmaceutical will be administered at 5 minutes (n=3), 10 minutes (n=3), and 20 minutes (n=3) after the start of image acquisition.
Cerebral blood flow change rate analysis: For each participant, the percentage change in cerebral blood flow (CBF) observed on SPECT imaging compared with the baseline time point will be quantitatively analyzed at the following three time points. Radiopharmaceutical injection reference times: 5 minutes, 10 minutes, and 20 minutes after injection.
Secondary Outcomes
No secondary outcomes reported
Investigators
Yong-il Shin
Professor
Pusan National University Yangsan Hospital