COLPOP 'Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study*

• Conditions: cystocele; pelvic organ prolaps; rectocele; prolaps; 10010761

• Registration Number: NL-OMON30888
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Women with POP undergoing vaginal hysterectomy with anterior and/or posterior repair, 35-75 years of age
- Women without POP undergoing abdominal or vaginal hysterectomy, 35-75 years of age

Exclusion Criteria

- No informed consent
- Gynaecologic oncologic disease
- Chronic inflammatory diseases (RA) of chronic infections (HIV, hepatitis)
- Minors or incapacitated adults

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint<br /><br>·Determination of the production, crosslinking status and degradation profiles<br /><br>of the different collagen types in patients with and without POP in relation to<br /><br>age, parity, BMI, and POP status<br /><br>· Comparison of the collagen metabolism of differentiated stem cells and<br /><br>vaginal fibroblasts, of patients with and without POP. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary study parameters<br /><br>Not applicable</p><br>