Comparison of the Effect of Collagen and Corticosteroid Intra-articular Injection on Function and Pain in Patients with First Carpometacarpal Joint Osteoarthritis

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 50

Inclusion Criteria

Patients with first carpometacarpal osteoarthritis based on radiographic criteria grade 2 and 3 and have moderate to severe pain (VAS>=5) in the first carpometacarpal joint for at least 3 months, which is resistant to drug treatment.

Exclusion Criteria

The patient's willingness to withdraw from the study at any stage of the design
The presence of any acute or chronic infection of the joint or around the joint
Pregnancy
Any intra-articular injection of the first carpometacarpal joint was performed during the last three months.
History of oral and systemic corticosteroid use in the last two weeks
Use of NSAIDs within 2 weeks prior to injection
Existence of inflammatory joint diseases such as rheumatoid arthritis, spondyloarthropathies, connective tissue diseases, gout, Paget's, septic arthritis
History of neurological syndromes caused by entrapment of the peripheral nerves of the hands, such as carpal tunnel syndrome
History of surgery in the hand
Recent history of severe trauma to the hand
Having a severe underlying disease such as uncontrolled diabetes
Autoimmune and platelet disorders, treatment with anticoagulant and antiplatelet drugs within 10 days before injection
Daily use of opioid and non-opioid analgesics
Taking topical painkillers
Hemarthrosis
Erythema or psoriatic lesions at the injection site

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain in base of thumb. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: Visual analogue scale (VAS).;Patient 's function. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: FIHOA questionnaire scores.;The strength of the thumb. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: Dynamometer.;The need for painkillers. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: questionnaire.

Secondary Outcome Measures