The Significance of Vitamin D Storage in Adipose Tissue
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- vitamin D in adipose tissue biopsies
研究概览
简要总结
The study will examine the role of adipose tissue in vitamin D physiology, particularly its role as a depot. the study is randomized double blind and placebo controlled.
详细描述
vitamin d versus placebo will be given for 12 months. Biopsies will be taken at baseline and every 6 month for 2 years. Blood samples will be collected every 6th month. the study will thus give information on storage during vitamin d supplementation as well as use of vitamin d fat stores after stopping vitamin D supplementation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects
排除标准
- •hypercalcemia
- •pregnancy
- •women without safe contraception
研究组 & 干预措施
cholecalciferol
vitamin d (cholecalciferol) will be given as a capsule of 20.000 Iu twice a week
干预措施: cholecalciferol (Drug)
placebo
the placebo capsules are looking identical to the vitamin d capsules and contain medium chain triglycerides and arachis oil
干预措施: placebo (Drug)
结局指标
主要结局
vitamin D in adipose tissue biopsies
时间窗: 12 months
次要结局
- rate of decline of 25ohd in serum(12 months)