Role of Fat Tissue in Vitamin D Metabolism

Completed

• Conditions: Vitamin D; Adipose Tissue

• Registration Number: NCT00033826
• Lead Sponsor: Tufts University

Brief Summary

Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.

Detailed Description

Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.

Study Timeline

• Study Start: 2002-04
• Study First Submitted: 2002-04-10
• Study First Submitted QC: 2002-04-10
• Study First Posted: 2002-04-11
• Primary Completion: 2007-09
• Study Completion: 2007-09
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-23
• Last Update Posted: 2013-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Obese patients referred for gastric bypass surgery

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Exclusion Criteria

• Patients must not be taking bile acid-sequestering medications or anti-seizure medications

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Tufts-New England Medical Center; 🇺🇸 Boston, Massachusetts, United States