1. Prevalence of Nutritional Risk-undernutrition-support in China-Euro-USA. 2. Impact of Nutrition Support on Outcome for Patient at Risk. 3. Impact of Nutrition Support on Outcome,Cost/Effectiveness for Patient at Risk.
概览
- 阶段
- 不适用
- 干预措施
- Nutrition support
- 疾病 / 适应症
- Malnutrition
- 发起方
- Peking Union Medical College
- 入组人数
- 2000
- 试验地点
- 26
- 主要终点
- Infectious complication
- 状态
- 招募中
- 最后更新
- 3个月前
概览
简要总结
- The aim of this large scale study to survey the prevalence of nutritional risk and malnutrition in China,Europe and USA.
- The impact of nutritional support for the patients at nutritional risk on clinical outcomes and cost-effectiveness
Already get the approval by Ethics Committee of Peking Union medical college and Johns Hopkins Hospital.
详细描述
Although it was often to hear that malnutrition ratio in Aisa hospitalized patient was 40%-70% , there was no evidence to elaborate the prevalence of nutritional risk and malnutrition on hospitalized patients of Asia. Also in USA no data for nutritional risk. In 2002, scientists group headed by Kondrup from : European Society for Parenteral and Enteral Nutrition demonstrated that randomized controlled clinical trials showed patients may get benefit from nutrition support when they with nutrition risk. Based on these evidences, a simpler method was established by European Society for Parenteral and Enteral Nutrition in year 2002 in Munich \& it was demonstrated useful to evaluate the appropriate use of nutrition support at present time. This method was named as Nutrition Risk Screening (NRS). We propose to survey the prevalence of malnutrition \& nutrition risk in large cities' large/middle size hospitalized patients in China, Europe and USA use NRS tool. As well, we also aim to figure out the current nutrition support status in current large/middle size hospitals through this survey. we also propose to evaluate the cost-effectiveness of parenteral nutrition, enteral nutrition and non-nutritional support, and to examine the clinical outcomes of nutritional support in certain patients at nutritional risk identified by NRS-2002. For international cooperation,our partners are Professor Kondrup of Europe and Professor Nolan from Johns Hopkins Hospital,there are students from a cooperative project with Johns Hopkins Hospital for Doctor of Philosophy students 2005-2011. In plan this protocol might be completed around 2016 also.
研究者
Zhu-ming Jiang
Professor of General Surgery,
Peking Union Medical College
入排标准
入选标准
- •patients be in hospital overnight
- •diagnoses according to the protocol of cohort study for cost effectiveness
排除标准
- •patients admitting from emergency department
- •patients who undergone operation before second morning of hospitalization
- •patients who dose not give Informed Consents
研究组 & 干预措施
Nutrition support
Nutrition support cohort means accept nutrition support，it was defined as ≥15kal/kg/d and \< 30kal/kg/d of non-protein calories (carbohydrate and/or fat) and amino acids or protein≥1g/kg/d for 5\~28 consecutive days.
Without nutritional support
Group received only intravenous 5 to 10% glucose and electrolyte infusions
结局指标
主要结局
Infectious complication
时间窗: Observation will be carried from admitting end until discharge
A infectious complication was defined as as the presence of recognized pathogens in body tissues that normally are sterile, confirmed by the results of culture and supported by clinical, radiologic or hematologic evidence of infection
次要结局
- cost effectiveness(Observation will be carried from admitting end until discharge)