Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection

Phase 2

Completed

• Conditions: Postoperative Complications; Postoperative Pancreatitis

• Registration Number: NCT01460615
• Lead Sponsor: Tampere University Hospital

Brief Summary

The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with cortisone treatment. Treatment is administered to high risk patients (defined by high amount of acinar cells in the cut edge of pancreas).

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Status Verified: 2011-10
• Study First Submitted: 2011-10-25
• Study First Submitted QC: 2011-10-26
• Study First Posted: 2011-10-27
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Last Update Submitted: 2018-11-27
• Last Update Posted: 2018-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Pancreaticoduodenectomy and distal pancreatectomy patients in Tampere University Hospital

Exclusion Criteria

• Patients with an ongoing cortisone treatment
• Cefuroxime allergy
• Chronic pancreatitis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative overall complications of pancreatic resection	within the first 30 days after surgery	e.g. Postoperative pancreatic fistula, delayed gastric emptying, postpancreatectomy hemorrhage, biliary fistula, wound infection, postoperative pancreatitis.

Trial Locations

Locations (1)

Tampere University Hospital; 🇫🇮 Tampere, Finland