TMR-IR: The effect of memory reactivation during sleep on the reprocessing of distressing Memories in healthy participants and PTSD (posttraumatic stress disorder) patients

Phase 4

Recruiting

Conditions: F43.1
Post-traumatic stress disorder

Registration Number: DRKS00026210

Lead Sponsor: niversitätsklinikum Lübeck, Zentrum für Integrative Psychiatrie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

current main diagnosis: PTSD
-sufficient stability and patient feels prepared for emotion-activating therapy
-motivational and organisational ressources (for 12 sessions, weekly à 90min within a maximum of 16 weeks)
-fluency in German language
-IQ > 80
-age 18-60

Exclusion Criteria

-odour disturbances (e.g. allergies, Post-Covid)
-pronounced sleep disturbances, that have been originated before traumatisation, shift work, time zone change, sleep apnoe
-alcohol/drug abuse or addiction
-medication that is not in line with trauma therapy, e.g. benzodiazepines, opiates
-neurological diseases (e.g.: epilepsia), history of brain damage (e.g.: concussion with lost of consciousness) or degenerative neurological disease (e.g. Parkinson, Dementia)
-comorbid psychotic disease, comorbid bipolar-I disease (current or in history)
-acute suizidality
-PTSD-therapy in history (=more than 2 sessions of IR)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical Diagnostic of PTSD (CAPS, LEC-5) and Sleep quality (PSQI) at three time points:<br>T0 (before begin of therapy), T1 (after the end of therapy/12 sessions within 12-16 weeks and T2 (6 months after the end of therapy)<br><br>Follow-up diagnostics PTSD: PCL-5, PTCI and sleep quality by a sleep protocol (at all 12 sessions during therapy, between T0 and T1)

Secondary Outcome Measures

Name	Time	Method
Differential diagnostic for PTSD, depression (BDI-2), anxiety (BAI) and Self-Efficacy (SWE) at three time points:<br>T0 (before begin of therapy), T1 (after the end of therapy/12 sessions within 12-16 weeks and T2 (6 months after the end of therapy)