COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation
Phase 4
Completed
- Conditions
- Infertility
- Interventions
- Drug: COOL-COS
- Registration Number
- NCT02288143
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and low-dose hMG on the number of oocytes retrieved.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 28
Inclusion Criteria
- Women scheduled to controlled ovarian stimulation for oocyte retrieval.
- Body mass index: 18-35 Kg/m2.
- Ultrasound scan up to the third day of a menstrual cycle with absence of a dominant and active follicle (follicle >10mm and serum estradiol ≥ 40 pg/L).
- Signing an informed consent.
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Exclusion Criteria
- No exclusion criteria.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description COOL-COS COOL-COS All women will receive the intervention: Letrozole, Clomiphene, and low-dose hMG for the controlled ovarian stimulation.
- Primary Outcome Measures
Name Time Method Number of oocytes retrieved 12 days
- Secondary Outcome Measures
Name Time Method Number of embryos 17 days Ovarian hyper-stimulation syndrome 1 month
Trial Locations
- Locations (1)
Setor de Reproducao Humana do HC-FMRP-USP
🇧🇷Ribeirao Preto, Sao Paulo, Brazil