NCT02288143已完成4 期
Evaluation of a Simplified Low-cost and Friendly Controlled Ovarian Stimulation Combining Oral Letrozole and Clomiphene Citrate: a Pilot Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Number of oocytes retrieved
研究概览
简要总结
This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and low-dose hMG on the number of oocytes retrieved.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women scheduled to controlled ovarian stimulation for oocyte retrieval.
- •Body mass index: 18-35 Kg/m
- •Ultrasound scan up to the third day of a menstrual cycle with absence of a dominant and active follicle (follicle >10mm and serum estradiol ≥ 40 pg/L).
- •Signing an informed consent.
排除标准
- •No exclusion criteria.
研究组 & 干预措施
COOL-COS
Experimental
All women will receive the intervention: Letrozole, Clomiphene, and low-dose hMG for the controlled ovarian stimulation.
干预措施: COOL-COS (Drug)
结局指标
主要结局
Number of oocytes retrieved
时间窗: 12 days
次要结局
- Number of embryos(17 days)
- Ovarian hyper-stimulation syndrome(1 month)
研究者
Wellington P Martins, MD
Associate Professor
University of Sao Paulo
研究点 (1)
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