Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients
- Registration Number
- NCT01127945
- Lead Sponsor
- Yonsei University
- Brief Summary
This is a prospective, single-center, randomized, controlled, open-label, pilot study to evaluate the effectiveness of high dose statin loading in acute heart failure patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Dyspnea at rest or minimal activity
- Tachypnea (respiratory rate > 20/min) or rales or pulmonary edema on chest X-ray
Exclusion Criteria
- Acute coronary Syndrome
- Hospitalization plan for PTCA or CABG
- Cardiogenic shock (Systolic Blood Pressure < 80mmHg)
- Uncontrolled hypertension (Systolic Blood Pressure > 180mmHg)
- Allergy, adverse drug reaction, hypersensitivity to statin
- Troponin > 5 times upper limit of normal (ULN)
- Creatinine kinase-MB level > 3 times ULN
- AST, ALT > 3 times ULN or acute hepatitis
- Current or past history of muscle disease, rhabdomyolysis
- Life expectancy < 6 months (e.g. metastatic malignancy, liver cirrhosis)
- Pregnancy or women at age of childbearing potential
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description atorvastatin 80mg statin - conventional therapy (for heart failure) statin -
- Primary Outcome Measures
Name Time Method hsCRP levels at hospital day #4 to investigate the effect of high dose statin loading on the change of serum NT-proBNP, hsCRP levels in patients with acute heart failure
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Severance Cardiovascular hospital, Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of