Association of gene polymorphisms with lung function decline in patients with asthma on inhaled corticosteroids - Association of gene polymorphisms with lung function decline in asthma
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 300
研究概览
简要总结
Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 2013;132:305-312 e303. -Nagasaki T, Matsumoto H, et al. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol. 133:1474-77 e2.2014 -Nagasaki T, Matsumoto H, et al. Using exhaled nitric oxide and serum periostin as a composite marker to identify severe steroid-insensitive asthma. Am J Respir Crit Care Med. 190:1449-52.2014 -Sunadome H, et al. IL4Ra and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype. Clin Exp Allergy, in press -Matsumoto H, et al. Staphylococcus aureus enterotoxin sensitization involvement and its association with CysLTR1 variant in different asthma phenotypes. Ann Allergy Asthma Immunol 2017, 118:197-203.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 25years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •Current smokers or ex smokers with 10 or more pack-years when the first spirometric data was taken. Patients with respiratory diseases other than asthma such as Churg Strauss syndrome, allergic bronchopulmonary aspergillosis, eosinophilic pneumonia, congestive heart disease, vocal cord dysfunction, interstitial pneumonia, bronchiectasia. Patients who are not adherent to ICS treatment (determined by physicians).