nderstanding patients with elevated pulmonary arterial pressure

Not Applicable

Completed

• Conditions: Pulmonary arterial hypertension; Circulatory System; Pulmonary hypertension

• Registration Number: ISRCTN34481181
• Lead Sponsor: Royal Free London NHS Foundation Trust

Brief Summary

2023 Results article in https://doi.org/10.1093/eurheartj/ehad532 (added 19/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-09
• Study Completion: 2021-08-31
• Last Update Posted: 29 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

1. Aged =18 years at time of the first right heart catheter (RHC) procedure within the eligibility period
2. =1 RHC procedure in one of the pulmonary hypertension specialist or approved centers within the eligibility period

Exclusion Criteria

1. Missing value for mean Pulmonary Arterial Pressure or Pulmonary Vascular Resistance at the right heart catheter (RHC) procedure
2. Received any Pulmonary arterial hypertension medications before the first RHC procedure
3. Lung and/or heart transplant any time before the first RHC procedure
4. Enrolled in any interventional clinical trial with an investigational product within the 3 months prior to, or at the time of, the first RHC procedure within the eligibility period

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Hospitalization measured using the incidence of inpatient hospitalization events due to any cause anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint<br>2. Mortality rates measured using the time to all-cause mortality anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint

Secondary Outcome Measures

Name	Time	Method
1. Quality of life measured using the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) or emPHasis-10 questionnaire anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint<br>2. Progression to Pulmonary Hypertension measured using the date of Right Heart Catheterisation (RHC) anytime during the observation period (01/01/2009 to 01/03/2020) when the measured mPAP is =25 mmHg for the first time after the index RHC from retrospective HES and ONS or ISD data collection at a single timepoint