Cardiometabolic and cognitive benefits of omega-3 polyunsaturated fatty acids and curcumin supplementation in older, sedentary and overweight/obese adults

Phase 3

Completed

• Conditions: Obesity; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Diet and Nutrition - Obesity; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12616000732482
• Lead Sponsor: Professor Peter Howe

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-06-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Age 50-80 years old (women must be >12 months postmenopausal)
BMI 25-40kg/m2
Self-reported physical activity level <150min per week
Consuming < 2 fish/seafood meals per week
Consuming up to 300mg/d of LCn-3 PUFA from fish oil supplements or enriched foods
No change in medication type or dose for 1 month before the intervention

Exclusion Criteria

Clinic BP >160mmHg systolic or 100mmHg diastolic (determined at screening)
Suspected dementia (ACE-III score <82/100)
Smokers or currently on nicotine therapy
Neurological conditions
Heart/kidney/liver disease
Insulin therapy
Regularly consuming more than four standard alcoholic drinks per day
Major depression as diagnosed by a health care professional
Illiterate
Unwilling to maintain pre-enrolment physical activity levels and dietary habits for the duration of the trial
Unwilling to refrain from consuming stimulants before each clinic visit
Unwilling to provide a blood sample
Have any other medical condition or treatments (including supplements) which, in the investigators’ opinion, may confound the outcome of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine in overweight/obese and sedentary older adults the effects of 16-week supplementation with DHA-rich fish oil (Omega Brain) and curcumin (Brain Active), alone or in combination, on CVR to hypercapnia, assessed by transcranial doppler (TCD) ultrasound. [Week 0 and 16 weeks post intervention commencement.]