A prospective observational study to determine the ultrasonographic assessment of diaphragm function as a predictor of extubation success in ventilated neonates in the NICU
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To determine the ultrasonographic assessment of diaphragm function as a predictor of extubation success in ventilated neonates in the NICU
研究概览
简要总结
We hypothesize that assessment of diaphragmatic dimensions and excursion, before planned extubation in neonates, may be helpful in predicting successful extubation of infants from mechanical ventilation. We further hypothesize that a combination of diaphragmatic function assessment, in association with lung sonography and the ratio of Oxygen Saturation to fraction of inspired Oxygen (SpO2:FiO2) would be a good predictor to success of extubation. We aim to evaluate the diaphragmatic dimensions and excursion in ventilated neonates prior to extubation, and create a prediction model for extubation success, based on diaphragm function, lung score and SF ratio as a predictor for success of extubation
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 0.00 Day(s) 至 28.00 Day(s)(—)
- 性别
- All
入选标准
- •All neonates admitted to NICU requiring mechanical ventilation for at least 48 hours of life, and planned for extubation as determined by the clinical team.
排除标准
- •Major life- threatening congenital malformations, major chromosomal anomalies
- •Major congenital heart diseases or lung disorders
- •Congenital anomalies related to the diaphragm as diaphragmatic hernias, and diaphragmatic paralysis
- •Pleural effusion or Pneumothorax with or without an intercostal drain in situ
- •Neonatal encephalopathy.
结局指标
主要结局
To determine the ultrasonographic assessment of diaphragm function as a predictor of extubation success in ventilated neonates in the NICU
时间窗: 48 hours
次要结局
- 1. To compare the predictive accuracy of ultrasonographic assessment of diaphragm function and ultrasound assessment of the lung (lung score) for successful extubation
研究者
Anurag Sanjeev Pikle
Bharati Vidyapeeth, Pune
