Role of Intravascular Ultrasound in Patients With End-stage Renal Disease on Dialysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- End Stage Renal Disease
- Sponsor
- Boston Medical Center
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Morphology of lesion
- Status
- Recruiting
- Last Updated
- 5 months ago
Overview
Brief Summary
Hemodialysis represents a life line of patients with end stage renal disease, who are commonly maintained on hemodialysis through catheters. Prolonged exposure to these catheters eventually damages the walls of veins, which results in stenosis at the local site. This condition is called central venous stenosis (CVS) and affects number of patients on hemodialysis in the United States and can compromise the dialysis efficacy. The current diagnostic modality for CVS is venography, which has several limitations. This study proposes to examine intravenous ultrasound (IVUS) as a potentially superior modality, which will provide additional information.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ESRD (end stage renal disease) patients at BMC (Boston Medical Center)
- •Receiving hemodialysis
- •Has a dialysis access malfunction
- •Undergoing a diagnostic fistulogram for the dialysis access malfunction
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Morphology of lesion
Time Frame: 18 months
The morphology of lesion will be defined as fibrotic and fibrofatty based on IVUS images.
Extent of stenosis
Time Frame: 18 months
The severity of venous stenosis will be assessed using venogram and IVUS results. It will be calculated as the percentage diameter or area reduction, expressed as the ratio of the MLD or MLA to the RVD or RVA.
Length of lesions
Time Frame: 18 months
The length of each lesion will be measured between points with \>50% diameter reduction in comparison to the referenced vein diameter and the referenced vein area at the pre-stenotic venous segment.