The Role of Doppler Ultrasound in Assessment of Local Factors Affecting Maturation of Arteriovenous Fistula in Hemodialysis Patient

Not Applicable

• Conditions: Doppler Ultrasound in Arteriovenous Fistula Preoperative Evaluation and Post-operative Periodic Monitoring
• Interventions: Diagnostic Test: doppler ultrasound

• Registration Number: NCT05082792
• Lead Sponsor: Sohag University

Brief Summary

the long term survival of the chronic kidney disease (CKD) patients depends on the adequacy of dialysis via good vascular access. the arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. pre-operative evaluation and periodic monitoring of the AVF after creation with well-defined applied criteria by color doppler ultrasound (CDUS) will help to reduce rate of access failure and achieve better cumulative patency rate of fistulas.

Detailed Description

In recent years, the improvement in the diagnosis and treatment of chronic kidney disease (CKD) has led to increase the number of patients who need hemodialysis, adequacy of which depends upon the appropriately placed vascular access. Although the arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis, there is still a high rate of failure to mature in clinical practice. To increase the use of AVFs, especially in the co-morbid patients, a thorough pre-operative evaluation and periodic monitoring after AVF creation by color doppler ultrasound (CDUS) allows placement of AVF in higher proportion of patients, and early detection of access dysfunction with subsequent intervention that reduce the rate of access failure.

Doppler ultrasound is the main imaging modality for assessment of dialysis access circuits as its gives information on the morphological criteria and evaluates the inflow and outflow flows. CDUS is non-invasive modality, of low cost, not using ionizing radiation or iodinated contrast media.

Study Timeline

• Status Verified: 2021-10
• Study Start: 2021-10-01
• Study First Submitted: 2021-10-15
• Study First Submitted QC: 2021-10-15
• Last Update Submitted: 2021-10-15
• Study First Posted: 2021-10-19
• Last Update Posted: 2021-10-19
• Primary Completion: 2022-03-31
• Study Completion: 2022-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

CKD and ESRD patients on hemodialysis, in whom native arteriovenous fistula operation is needed

• both sexes are included.
• age group from 15-80years
• upper limb arteriovenous fistula only.
• native arteriovenous fistula.
• surgically succeeded AVF

Exclusion Criteria

we will exclude:

• patients refused to be in the research.
• Patients with AVF not in the upper limbs.
• Patient of age less than 15years and above 80years.
• patients with synthetic grafts.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
doppler US for native AVF in upper limb	doppler ultrasound	creation of native arteriovenous fistula in upper limb in chronic kidney disease patients on hemodialysis

Primary Outcome Measures

Name	Time	Method
maturation of AVF	6 months	maturation is considered successful if the fistula patent has a diameter \>6mm, located \<6mm maximum depth from skin surface, with PSV 400cm/s, flow volume 600ml/min, within 6 weeks post-surgery

Trial Locations

Locations (1)

Sohag University; 🇪🇬 Sohag, Egypt