Perfusion imaging by arterial spin labelling for clinical use in stroke

Recruiting

• Conditions: I65.2; I66.0; I63.2; I63.5; Occlusion and stenosis of carotid artery; Occlusion and stenosis of middle cerebral artery; Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries; Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries

• Registration Number: DRKS00003198
• Lead Sponsor: Charité Campus Charité Mitte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

In-patient or out-patient, neurologically or hemodynamically stable state, one of the following cerebrovascular pathologies:

High grade stenosis (>70%) of the common carotid artery,

High grade stenosis (>70%) of the internal extracranial carotid artery,

High grade stenosis (>70%) of the internal intracranial carotid artery,

High grade stenosis (>70%) of the middle cerebral artery, proximal part M1,

High grade stenosis (>70%) of the middle cerebral artery, distal parts M2/M3.

Exclusion Criteria

MR-contraindications, patients with magnetic implants (pacemaker), claustrophobia, clinically unstable status, unability to give informed consent due to aphasia or reduced vigilance, allergic reaction to gadolinium-based contrast agents, renal insufficiency (GFR = 30 ml/min/1,73 m²), pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CBF (crebral blood flow) in an outlined region of interest (ROI) measured by ASL (arterial spin labelling) and PWI (perfusion weighted imaging)