An effectiveness of arterial spin labeling perfusion MRI combined with contrast MRI for determination of tumor typess

Not Applicable

• Conditions: Metastatic brain tumor Glioma Lymphoma

• Registration Number: JPRN-UMIN000018485
• Lead Sponsor: Tokushima university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-01
• Study Completion: 2020-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Patients who meet any of the following criteria are not eligible for the study: 1.Contraindication of MRI exam. Patients who have a heart pacemaker, cochlear implant, metallic foreign body, metallic devices 2.Patients who have history of hypersensitivity for Gd contrast media 3.Patients with severe CKD(eGFR<30mL/min/m2) 4.Pregnancy 5.Any others judged ineligible as a subject by the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
on-Inferiority of diagnostic concordance among high grade glioma, Lymphoma and Metastasis by ASL-MRI in comparison with DSC-MRI.

Secondary Outcome Measures

Name	Time	Method
1. Relationship between category based on discrepancy between ASL imaging and enhanced MR imaging, histological findings of brain tumors. 1. Category : "ASL dominant", and "CE dominant" 2. Diagnostic performance of recurrence and radionecrosis (in primary tumors) by ASL-MRI (Sensitivity, Specificity, PPV, NPV by quantitative evaluation) 3. Relationship between ASL(CBF ) and DSC(CBV, CBF, MTT, Tmax) parameters.