Serial arterial spin labeling perfusion MRI in acute ischemic stroke: detecting incomplete microvascular reperfusion.

Withdrawn

Conditions: acute ischemic stroke
10047075

Registration Number: NL-OMON47938

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

-A clinical diagnosis of acute ischemic stroke
-Age 18 years or older
-NIHSS >/=2
-Treated with intravenous tPA <4.5 h after symptom onset and/or treated with
EVT <6 hours after
symptom onset for a large vessel occlusion of the anterior circulation
(distal intracranial carotid artery or middle cerebral artery (M1 segment or
proximal M2 segment))
confirmed by neuroimaging (CTA or MRA) resulting in a successful
recanalization (defined as
mTICI 2B-3)
-Written informed consent obtained

Exclusion Criteria

-Any previous stroke or known neurological disorder associated with structural
brain abnormalities
-Any contra-indication for MRI (e.g. ferromagnetic implant(s), claustrophobia,
pacemaker)
-Clinical condition unsuited for repetitive MRI imaging or prolonged stay at
the Radiology department.
-Pre-stroke modified Rankin Scale score > 2
-Participation in stroke trials interfering with the current study

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of this study is the delta Cerebral Blood Flow (CBF) and<br /><br>infarct volume between time points 0 and 60 minutes.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes are the changes in CBF and concordant infarct volume<br /><br>evolution over different time points early after treatment (+30, +90, +120,<br /><br>+240 minutes). </p><br>