Arterial spin labelling for the assessment of cerebral autoregulation - a proof of principle

Completed

• Conditions: Alzheimer's Disease; dementia; 10042258; 10003216

• Registration Number: NL-OMON42505
• Lead Sponsor: Radboudumc

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- Written informed consent
- Age 18-40 or age 55-75

Exclusion Criteria

-Subjects who cannot have an MRI, e.g. due to claustrophobia, metal in upper body, have an implant or who suffer from epilepsy.
oIncreased risk on coronary spasms
oRecent (< 3 months) angina pectoris, myocardial infarct, brain infarct and/or heart failure.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• Relative cerebral blood flow changes over time (every 5s)<br /><br>• Relative blood pressure changes over time (every 5s)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Feasibility:<br /><br>o # of deviations from protocol<br /><br>o # of motion artifacts in ASL images<br /><br>o # of motion artifacts in CareTaker<br /><br>Validity<br /><br>o Oscillations in mean cerebral blood flow<br /><br>*- rASL<br /><br>*- NIRS<br /><br>o Oscillations in MAP<br /><br>*- CareTaker<br /><br>*- Finapres<br /><br>To assess the magnitude of changes that can be detected<br /><br>o Variation due to physiological changes<br /><br>o Variation due to measurement noise </p><br>