Renal Perfusion Assessment in the Endovascular Treatment of Renal Artery Stenosis

Recruiting

• Conditions: Renal Artery Stenosis

• Registration Number: NCT05603221
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

The clinical benefits of endovascular treatment in renal artery stenosis remain controversial. This study uses arterial spin labelling MRI and flat-panel detector parenchymal blood volume imaging to observe the change in renal perfusion after endovascular treatment in renal artery stenosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-04
• Status Verified: 2022-10
• Study First Submitted: 2022-10-23
• Study First Submitted QC: 2022-10-27
• Last Update Submitted: 2022-10-27
• Study First Posted: 2022-11-02
• Last Update Posted: 2022-11-02
• Primary Completion: 2024-06-30
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients who provided informed consent
• patients who were diagnosed with RAS by CTA, MRA, or Doppler ultrasonography
• patients who were aged 18 years or older
• patients whose intervened renal arteries were not completely occluded (confirmed by DSA)
• the stenosis percentage exceeding 70%
• patients who had uncontrolled blood pressure or impaired renal function
• paitents whose affected kidney did not have total loss of function

Exclusion Criteria

• were pregnant
• had a history of renal transplantation or renal artery bypass surgery
• were allergic to iodine contrast medium
• had other contraindications of endovascular treatment
• contraindications of MRI examinations
• had technical failure in the endovascular treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Perfusion of the target kidney assessed by Arterial Spin Labelling MRI	Changes from baseline renal perfusion at 2 months
Perfusion of the target kidney assessed by Flat-panel Detector Parenchymal Blood Volume Imaging	Changes from baseline renal perfusion immediately after endovascular intervention

Secondary Outcome Measures

Name	Time	Method
Blood pressure	Changes from baseline blood pressure at 1 year
Renal function	Changes from baseline renal function at 1 year

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, China