Renal Arterial Spin Labelling in chronic Kidney disease

Not Applicable

Completed

• Conditions: Renal, Kidney perfusion, Magnetic resonance imaging; Urological and Genital Diseases; Chronic kidney disease

• Registration Number: ISRCTN12301736
• Lead Sponsor: HS Greater Glasgow and Clyde (UK)

Brief Summary

1. 2016 results in https://www.ncbi.nlm.nih.gov/pubmed/27362585 (added 22/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-12-18
• Study Completion: 2015-02-01
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1. Aged over 18 years
2. Written informed consent
3. CKD - people with chronic kidney disease stages 3 - 5, with an eGFR 15-30ml/min
4. LKD - people being assessed to act as live kidney donors
5. RVD - people with renovascular disease documented on imaging and after assessment by a nephrologist

Exclusion Criteria

1. Known liver disease (alcoholic liver disease, hepatitis, cirrhosis)
2. Known HIV infection
3. Known recreational drug or alcohol abuse
4. Clinical signs of acute infection
5. Known pregnancy
6. Women of childbearing age are who are at risk of pregnancy
7. Metal prosthesis contraindicating MRI
8. Claustrophobia contraindicating MRI

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in renal perfusion by ASL MRI, measured after saline and then after ascorbic acid

Secondary Outcome Measures

Name	Time	Method
<br> Biomarkers of oxidative stress both measured after saline and then after ascorbic acid<br> 1. Total antioxidant capacity measured by colorimetric assay<br> 2. Rate of reactive oxygen species generation measured by electron paramagnetic resonance<br>