CTRI/2023/05/052753
Not yet recruiting
未知
Comparative study of efficacy and adverse effect profile of treatment with methotrexate (0.3 mg/kg/week) versus a combination of low dose of methotrexate (0.15 mg/kg/week) plus low dose of acitretin (0.3 mg/kg/day) in chronic plaque psoriasis
Department of Dermatology and Venereology0 sites0 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Department of Dermatology and Venereology
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients of age 18\-65 years
- •2\. Given their consent to participate in the study
- •3\. BSA \>10, PASI \>10
- •4\. Cumulative methotrexate dose \< 1\.5 gm
- •5\. Not taking any systemic therapy for 1 month prior to enrolment
- •6\. Not applying topical therapy for 2 weeks prior to enrolment
Exclusion Criteria
- •1\. Pregnancy or lactation
- •2\. History of alcoholism
- •3\. Taking hepatotoxic or nephrotoxic drugs
- •4\. History of prior treatment with oral retinoids
- •5\. Hemoglobin \< 8 gm/ dL
- •6\. TLC \< 4000 cells/mm3
- •7\. Platelet count \< 1 lakh/mm3
- •8\. Lymphocytes \< 1500/mm3
- •9\. Raised SGPT/OT \>\= twice the normal limit at baseline or \>\= thrice the normal limit at follow up
- •10\. Raised total bilirubin \> 1\.2 or 30 % increase in baseline
Outcomes
Primary Outcomes
Not specified
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