Comparative study of efficacy and adverse effect of treatment with methotrexate versus a combination of methotrexate plus acitretin in chronic plaque psoriasis.

Not Applicable

• Conditions: Health Condition 1: L400- Psoriasis vulgaris

• Registration Number: CTRI/2023/05/052753
• Lead Sponsor: Department of Dermatology and Venereology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Patients of age 18-65 years

2. Given their consent to participate in the study

3. BSA >10, PASI >10

4. Cumulative methotrexate dose < 1.5 gm

5. Not taking any systemic therapy for 1 month prior to enrolment

6. Not applying topical therapy for 2 weeks prior to enrolment

Exclusion Criteria

1. Pregnancy or lactation

2. History of alcoholism

3. Taking hepatotoxic or nephrotoxic drugs

4. History of prior treatment with oral retinoids

5. Hemoglobin < 8 gm/ dL

6. TLC < 4000 cells/mm3

7. Platelet count < 1 lakh/mm3

8. Lymphocytes < 1500/mm3

9. Raised SGPT/OT >= twice the normal limit at baseline or >= thrice the normal limit at follow up

10. Raised total bilirubin > 1.2 or 30 % increase in baseline

11. Serum creatinine values of > 1.4 mg/dl at baseline or more than 30% increase in baseline at two consecutive visits.

12. Tuberculosis, any reliable sign of infection, signs and symptoms suggestive of immunosuppression, or any chronic disease

13. Peptic ulcers

Study & Design

• Study Type: Interventional
• Study Design: Not specified