CTRI/2023/05/052753尚未招募Unknown
Comparative study of efficacy and adverse effect profile of treatment with methotrexate (0.3 mg/kg/week) versus a combination of low dose of methotrexate (0.15 mg/kg/week) plus low dose of acitretin (0.3 mg/kg/day) in chronic plaque psoriasis
Department of Dermatology and Venereology0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients of age 18-65 years
- •2. Given their consent to participate in the study
- •3. BSA >10, PASI >10
- •4. Cumulative methotrexate dose < 1.5 gm
- •5. Not taking any systemic therapy for 1 month prior to enrolment
- •6. Not applying topical therapy for 2 weeks prior to enrolment
排除标准
- •1. Pregnancy or lactation
- •2. History of alcoholism
- •3. Taking hepatotoxic or nephrotoxic drugs
- •4. History of prior treatment with oral retinoids
- •5. Hemoglobin < 8 gm/ dL
- •6. TLC < 4000 cells/mm3
- •7. Platelet count < 1 lakh/mm3
- •8. Lymphocytes < 1500/mm3
- •9. Raised SGPT/OT >= twice the normal limit at baseline or >= thrice the normal limit at follow up
- •10. Raised total bilirubin > 1.2 or 30 % increase in baseline
- •11. Serum creatinine values of > 1.4 mg/dl at baseline or more than 30% increase in baseline at two consecutive visits.
- •12. Tuberculosis, any reliable sign of infection, signs and symptoms suggestive of immunosuppression, or any chronic disease
- •13. Peptic ulcers
研究者
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