A Study on the Inter-Hemispheric Alpha Ratio in Kids With ADHD (SHARK)

Completed

• Conditions: ADHD

• Registration Number: NCT01932398
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Investigate the hypothesis that children with ADHD have difficulty with the allocation of visio-spatial attention related to an inability to control posterior alpha brain oscillations. A paradigm will be used in which the aim is to address covert attention as similar recent studies did in adults with ADHD.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2013-08-22
• Study First Submitted QC: 2013-08-27
• Study First Posted: 2013-08-30
• Status Verified: 2015-01
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Last Update Submitted: 2015-01-19
• Last Update Posted: 2015-01-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For both groups

• Age between 7 and 10 years of age.
• Estimated IQ above 80.
• Psychopharmaca- naïve or -free.

For the ADHD-group - A diagnosis of ADHD, classified by the DSM-IV.

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Exclusion Criteria

• (Co-morbid) psychiatric disorder (major depression, bipolar disorder, psychotic disorder, chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, autism spectrum disorder, eating disorder, anxiety disorder).
• Neurological disorders (e.g. epilepsy) currently or in the past.
• Cardiovascular disease currently or in the past.
• Serious motor or perceptual handicap.

For the no ADHD-group

• No diagnosis of ADHD, classified by the DSM-IV.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Modualtion of alpha power	Once for half an hour	Modulation\* of alpha power on congruent and incongruent trials of the covert attention task in 30 ADHD children and in 30 non-ADHD children; \*Modulation is the (expected) cue-induced change by a covert attention task.

Secondary Outcome Measures

Name	Time	Method
Mean deviation from middle on line bisection task	Once in about 5 minutes	Mean deviation in mm from the center of the line on the line bisection task for 30 ADHD children and 30 non-ADHD children
Inattention score on the ADHD-RS-IV	Once in about 10 minutes	The inattention subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children
Standard deviation of response time on covert attention task	Once for half an hour	The variation of the time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Response time on covert attention task	Once for half an hour	Time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Correct responses on covert attention task	Once for half an hour	Number of correct button presses responses (i.e. same side as the target) on the covert attention task on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Hyperactivity/impulsivity score on the ADHD-RS-IV	Once in about 10 minutes	The hyperactivity/impulsivity subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children

Trial Locations

Locations (1)

Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging; 🇳🇱 Nijmegen, Gelderland, Netherlands